Reovirus RNA Transcrition

   This In3D animation highlights the inital steps of RNA transscription by the RNA-dependent RNA polymerase from reovirus. In this animation you will observe several stages of transcription initiation.

   Beginning with a quick orientation of the enzyme itself, the viewer is then shown the capped RNA template that will later be used for initiation of transcription. The capped RNA binds in a special cleft on the enxyme surface. Following binding, the 3'-end of the RNA is fed into the enzyme actve site, where stranscription initiation occurs. Transcription begins with the formation of a pppGpG dimer (shown). Following formation of the dimer elongation comenses ielding full length RNA of the opposite polarity.

   The In3D effect observable here is typical of that observed using our special encoding process.